The increase of hospital infection due to methicillin Staphylococcus aureus(MRSA) became one of the most important problem in treatment. In order to investigate the epidemiological characteristantics of MRSA, 140 strains and 92 strains (232
strains
in
total) of Staphylococcus aureus were isolated from various specimens each of two hospitals located in Kwangju city, and their antimicrobial resistance patterns against 19 kinds of antimicrobial agents and phage types were studied.
1. The resistance frequency to methicillin was 72.9% in the strains from hospital A, which was about 30% higher than that of hospital B, 34.7%.
2. The most frequently observed multiple resistance patterns in the strains from A hospital were OxaApCftCfzCfmMxFmCmTmLmAkNmTcEmRf(12 strains), and next were OxaApCftCfzMxGmTmLmAkNmTcEmRf (11 strains), OxaApCftCfzMxFmGmTmLmAkNmTcEmRf (9
strains).
Among
B hospital isolates, strains with resistance with resistance to OxaApCftCfzMxFmGmTmLmAkCmTcEm was the most frequent (11 strains).
3. The phage type showed the different pattern between MRSA and methicillin-sensitive Staphylococcus aureus (MSSA). Various phage types belonging to each group were shown in the MSSA isolated from A hospital, on the other hand, in the MRSA the
phage
type belonging to groupⅢwas shown to be the most one as 61.6%, and in paticular, phage type 85 appeared as 58.9%. In the MSSA isolated from B hospital, groupⅢphage appeared as highly as 42%, but the phage types were various. In the MRSA, group
I
phage
was 31%, groupⅢwas 40.5%, and in particular type 52A(19%) and type 85(26%) were notable in group I and groupⅢ, respectively.
4. In the MRSA, it Was very likely that the strains with the same antimicrobial resistance pattern showed the similar phage type. It was also shown that the resistance patterns and phage types was different between the strains isolated from
hospital A
and hospital B.
In summary, most of MRSA causing hospital infection showed different patterns in each hospital and it was estimated that MRSA depends on the individual hospital environment.
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